Which dosage form cannot be substituted from Brand to generic?

The correct answer is that enteric coated tablets cannot be substituted from brand to generic. The primary reason for this is that enteric coating is specifically designed to protect the active ingredient from being released in the acidic environment of the stomach; instead, it allows for the release to occur in the more alkaline environment of the intestines.

This specialized formulation can significantly affect the absorption and overall effectiveness of the medication. When a patient is prescribed an enteric coated tablet, the unique characteristics of that dosage form must be maintained to ensure that the therapeutic effect is achieved as intended. A generic version may not necessarily match the release profile, absorption characteristics, or other pharmacokinetic and pharmacodynamic properties of the original brand product.

In contrast, other dosage forms such as standard tablets, liquids, and soft gels generally do not have such specialized release mechanisms and can be more easily substituted as generics, provided that they meet the necessary bioequivalence standards.